{"entity":{"id":"zen-3694-abemaciclib-nut","kind":"trial","name":"ZEN-3694 with abemaciclib in NUT carcinoma, breast cancer and other solid tumours (NCI phase 1)","aka":[],"tldr":"A chemotherapy-free combination for NUT carcinoma: a BET inhibitor with a CDK4/6 inhibitor, on the reasoning that both act on the MYC-driven growth programme the fusion switches on.","summary":"BRD4-NUT keeps MYC and other growth genes switched on; BET inhibition alone gives short responses. This NCI phase 1 study adds abemaciclib, a CDK4/6 inhibitor, to ZEN003694 in patients with NUT carcinoma, advanced breast cancer and other solid tumours, to find a tolerable dose and look for activity. It is recruiting.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05372640","url":"https://clinicaltrials.gov/study/NCT05372640"}],"tags":["owner-request"],"related":[],"cancers":["nut-carcinoma"],"sections":[],"technologies":["epigenetic-drugs"],"targets":["cdk4-6"],"drugs":["zen-3694","abemaciclib"],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05372640","phase":"1","setting":"NUT carcinoma, advanced breast cancer and other solid tumours: BET inhibitor ZEN003694 with the CDK4/6 inhibitor abemaciclib; started August 2023, 45 planned","sponsor":"National Cancer Institute (NCI)","enrolled":45,"outcomes":[]},"route":"/trials/zen-3694-abemaciclib-nut/","neighbours":{"cancer":[{"id":"nut-carcinoma","kind":"cancer","name":"NUT carcinoma (midline carcinoma with NUTM1 rearrangement)","route":"/cancers/nut-carcinoma/"}],"technology":[{"id":"epigenetic-drugs","kind":"technology","name":"Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)","route":"/technologies/epigenetic-drugs/"}],"target":[{"id":"cdk4-6","kind":"target","name":"CDK4/6","route":"/targets/cdk4-6/"}],"drug":[{"id":"abemaciclib","kind":"drug","name":"Abemaciclib","route":"/drugs/abemaciclib/"},{"id":"zen-3694","kind":"drug","name":"ZEN-3694","route":"/drugs/zen-3694/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}]}}