{"entity":{"id":"zen-3694-platinum-nut","kind":"trial","name":"ZEN-3694 with platinum chemotherapy in NUT carcinoma (NCI phase 1/2)","aka":[],"tldr":"The main open trial for NUT carcinoma, pairing a BET inhibitor that attacks the BRD4-NUT fusion directly with the platinum chemotherapy patients would otherwise receive alone.","summary":"NUT carcinoma is driven by a fusion of NUTM1 to BRD4 or another BET protein, so BET bromodomain inhibitors are its most rational drugs; single agents produced responses but not durable ones. This National Cancer Institute study tests ZEN003694 with platinum-based chemotherapy in advanced NUT carcinoma, with a dose-finding phase 1 leading into phase 2. It is recruiting.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05019716","url":"https://clinicaltrials.gov/study/NCT05019716"}],"tags":["owner-request"],"related":[],"cancers":["nut-carcinoma"],"sections":[],"technologies":["epigenetic-drugs","cytotoxic-chemotherapy"],"targets":[],"drugs":["zen-3694","cisplatin","etoposide"],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05019716","phase":"1/2","setting":"Advanced, metastatic or unresectable NUT carcinoma: the BET bromodomain inhibitor ZEN003694 added to platinum-based chemotherapy; started July 2022, 36 planned","sponsor":"National Cancer Institute (NCI)","enrolled":36,"outcomes":[]},"route":"/trials/zen-3694-platinum-nut/","neighbours":{"cancer":[{"id":"nut-carcinoma","kind":"cancer","name":"NUT carcinoma (midline carcinoma with NUTM1 rearrangement)","route":"/cancers/nut-carcinoma/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"epigenetic-drugs","kind":"technology","name":"Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)","route":"/technologies/epigenetic-drugs/"}],"drug":[{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"},{"id":"zen-3694","kind":"drug","name":"ZEN-3694","route":"/drugs/zen-3694/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}]}}