{"entity":{"id":"zfhx4","kind":"target","name":"ZFHX4","aka":["zinc finger homeobox 4","Zinc finger homeobox protein 4","ZFH4","FLJ20980"],"tldr":"ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, animal model 0.43, genetic association 0.63).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30939","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30939"},{"label":"UniProt Q86UP3","url":"https://www.uniprot.org/uniprotkb/Q86UP3/entry"},{"label":"NCBI Gene 79776","url":"https://www.ncbi.nlm.nih.gov/gene/79776"},{"label":"Ensembl ENSG00000091656","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091656"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZFHX4","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:30939","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30939","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86UP3","url":"https://www.uniprot.org/uniprotkb/Q86UP3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000091656","url":"https://platform.opentargets.org/target/ENSG00000091656/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:30939","ensembl":"ENSG00000091656","uniprot":"Q86UP3","entrez":"79776","biology":"May play a role in neural and muscle differentiation. May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/zfhx4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}