{"entity":{"id":"zhx2","kind":"target","name":"ZHX2","aka":["zinc fingers and homeoboxes 2","Zinc fingers and homeoboxes protein 2","KIAA0854"],"tldr":"ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.","summary":"Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18513","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18513"},{"label":"UniProt Q9Y6X8","url":"https://www.uniprot.org/uniprotkb/Q9Y6X8/entry"},{"label":"NCBI Gene 22882","url":"https://www.ncbi.nlm.nih.gov/gene/22882"},{"label":"Ensembl ENSG00000178764","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178764"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["papillary-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZHX2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18513","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18513","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6X8","url":"https://www.uniprot.org/uniprotkb/Q9Y6X8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ZHX2","url":"https://civicdb.org/features/9121","note":"1 evidence items, 0 assertions, 1 variants; diseases: Papillary Renal Cell Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:18513","ensembl":"ENSG00000178764","uniprot":"Q9Y6X8","entrez":"22882","biology":"Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Location: Nucleus (UniProt). Locus 8q24.13 (HGNC).","whereFound":["Papillary renal cell carcinoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/zhx2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"papillary-rcc","kind":"cancer","name":"Papillary renal cell carcinoma","route":"/cancers/papillary-rcc/"}]}}