{"entity":{"id":"zmiz1","kind":"target","name":"ZMIZ1","aka":["zinc finger MIZ-type containing 1","Zinc finger MIZ domain-containing protein 1","RP11-519K18.1","KIAA1224","FLJ13541","hZIMP10","Zimp10","RAI17"],"tldr":"ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer.","summary":"Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.73).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16493"},{"label":"UniProt Q9ULJ6","url":"https://www.uniprot.org/uniprotkb/Q9ULJ6/entry"},{"label":"NCBI Gene 57178","url":"https://www.ncbi.nlm.nih.gov/gene/57178"},{"label":"Ensembl ENSG00000108175","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108175"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","prostate","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZMIZ1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16493","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9ULJ6","url":"https://www.uniprot.org/uniprotkb/Q9ULJ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000108175","url":"https://platform.opentargets.org/target/ENSG00000108175/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: colorectal cancer 0.55, prostate cancer 0.55, breast cancer 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:16493","ensembl":"ENSG00000108175","uniprot":"Q9ULJ6","entrez":"57178","biology":"Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signalling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Location: Nucleus, nucleoplasm; Cytoplasm; Nucleus (UniProt). Locus 10q22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/zmiz1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}