{"entity":{"id":"zmym2","kind":"target","name":"ZMYM2","aka":["zinc finger MYM-type containing 2","Zinc finger MYM-type protein 2","ZNF198"],"tldr":"ZMYM2 (Zinc finger MYM-type protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Non-Hodgkin lymphoma and 1 more.","summary":"Involved in the negative regulation of transcription.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.65, genetic association 0.28, somatic mutation 0.43, animal model 0.41). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12989","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12989"},{"label":"UniProt Q9UBW7","url":"https://www.uniprot.org/uniprotkb/Q9UBW7/entry"},{"label":"NCBI Gene 7750","url":"https://www.ncbi.nlm.nih.gov/gene/7750"},{"label":"Ensembl ENSG00000121741","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121741"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["leukaemia","prostate","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZMYM2","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:12989","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12989","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UBW7","url":"https://www.uniprot.org/uniprotkb/Q9UBW7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000121741","url":"https://platform.opentargets.org/target/ENSG00000121741/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.53, non-Hodgkin lymphoma 0.53, leukaemia 0.61 (GraphQL API, CC0)"},{"label":"IntOGen ZMYM2","url":"https://www.intogen.org/search?gene=ZMYM2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12989","ensembl":"ENSG00000121741","uniprot":"Q9UBW7","entrez":"7750","biology":"Involved in the negative regulation of transcription. Location: Nucleus (UniProt). Locus 13q12.11 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/zmym2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}