{"entity":{"id":"zmym3","kind":"target","name":"ZMYM3","aka":["zinc finger MYM-type containing 3","Zinc finger MYM-type protein 3","ZNF198L2","DXS6673E","KIAA0385","ZNF261"],"tldr":"ZMYM3 (Zinc finger MYM-type protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 4 more.","summary":"Required for regulation of cell morphology and cytoskeletal organisation.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.00, somatic mutation 0.79). IntOGen calls it a driver in 15 cohorts (6 activating, 9 loss-of-function), covering Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Head and Neck Squamous Cell Carcinoma, Lung Adenocarcinoma, Medulloblastoma, Prostate Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13054","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13054"},{"label":"UniProt Q14202","url":"https://www.uniprot.org/uniprotkb/Q14202/entry"},{"label":"NCBI Gene 9203","url":"https://www.ncbi.nlm.nih.gov/gene/9203"},{"label":"Ensembl ENSG00000147130","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147130"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate","breast-cancer","head-and-neck","cll","medulloblastoma","nsclc","thymoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 6 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 9 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZMYM3","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:13054","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13054","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14202","url":"https://www.uniprot.org/uniprotkb/Q14202/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000147130","url":"https://platform.opentargets.org/target/ENSG00000147130/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: prostate cancer 0.57 (GraphQL API, CC0)"},{"label":"IntOGen ZMYM3","url":"https://www.intogen.org/search?gene=ZMYM3","note":"driver in 15 cohorts (Act 6, LoF 9); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13054","ensembl":"ENSG00000147130","uniprot":"Q14202","entrez":"9203","biology":"Required for regulation of cell morphology and cytoskeletal organisation. Location: Nucleus (UniProt). Locus Xq13.1 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.57 with prostate cancer (MONDO_0008315); IntOGen driver in 7 cohorts (PRAD, PROSTATE)","Breast cancer: IntOGen driver in 1 cohort (BRCA)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Chronic lymphocytic leukaemia: IntOGen driver in 2 cohorts (CLLSLL)","Medulloblastoma: IntOGen driver in 2 cohorts (MBL)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/zmym3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"thymoma","kind":"cancer","name":"Thymoma (WHO types A, AB, B1, B2 and B3)","route":"/cancers/thymoma/"}]}}