{"entity":{"id":"znf208","kind":"target","name":"ZNF208","aka":["zinc finger protein 208","Zinc finger protein 208","PMIDP","ZNF95"],"tldr":"ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.","summary":"May be involved in transcriptional regulation.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Oesophageal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12999","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12999"},{"label":"UniProt O43345","url":"https://www.uniprot.org/uniprotkb/O43345/entry"},{"label":"NCBI Gene 7757","url":"https://www.ncbi.nlm.nih.gov/gene/7757"},{"label":"Ensembl ENSG00000160321","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160321"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["esophageal","oesophageal-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF208","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:12999","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12999","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43345","url":"https://www.uniprot.org/uniprotkb/O43345/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZNF208","url":"https://www.intogen.org/search?gene=ZNF208","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12999","ensembl":"ENSG00000160321","uniprot":"O43345","entrez":"7757","biology":"May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/znf208/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}]}}