{"entity":{"id":"znf217","kind":"target","name":"ZNF217","aka":["zinc finger protein 217","Zinc finger protein 217","ZABC1"],"tldr":"ZNF217 (Zinc finger protein 217) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer and Osteosarcoma.","summary":"Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonises cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Triciribine. Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13009","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13009"},{"label":"UniProt O75362","url":"https://www.uniprot.org/uniprotkb/O75362/entry"},{"label":"NCBI Gene 7764","url":"https://www.ncbi.nlm.nih.gov/gene/7764"},{"label":"Ensembl ENSG00000171940","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171940"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["breast-cancer","ovarian","osteosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF217","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13009","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13009","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75362","url":"https://www.uniprot.org/uniprotkb/O75362/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ZNF217","url":"https://civicdb.org/features/6281","note":"4 evidence items, 0 assertions, 2 variants; diseases: Breast Cancer, Ovarian Cancer, Osteosarcoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000171940","url":"https://platform.opentargets.org/target/ENSG00000171940/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:13009","ensembl":"ENSG00000171940","uniprot":"O75362","entrez":"7764","biology":"Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonises cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. Location: Nucleus (UniProt). Locus 20q13.2 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease","Ovarian cancer: CIViC evidence names this disease","Osteosarcoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/znf217/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"osteosarcoma","kind":"cancer","name":"Osteosarcoma","route":"/cancers/osteosarcoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}