{"entity":{"id":"znf274","kind":"target","name":"ZNF274","aka":["zinc finger protein 274","Neurotrophin receptor-interacting factor homolog","ZKSCAN19","ZSCAN51"],"tldr":"ZNF274 (Neurotrophin receptor-interacting factor homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.","summary":"Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13068","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13068"},{"label":"UniProt Q96GC6","url":"https://www.uniprot.org/uniprotkb/Q96GC6/entry"},{"label":"NCBI Gene 10782","url":"https://www.ncbi.nlm.nih.gov/gene/10782"},{"label":"Ensembl ENSG00000171606","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171606"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF274","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:13068","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13068","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96GC6","url":"https://www.uniprot.org/uniprotkb/Q96GC6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZNF274","url":"https://www.intogen.org/search?gene=ZNF274","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13068","ensembl":"ENSG00000171606","uniprot":"Q96GC6","entrez":"10782","biology":"Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 19q13.43 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/znf274/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}]}}