{"entity":{"id":"znf331","kind":"target","name":"ZNF331","aka":["zinc finger protein 331","Zinc finger protein 331","ZNF463","ZNF361"],"tldr":"ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.","summary":"May be involved in transcriptional regulation. May play a role in spermatogenesis.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.14, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15489"},{"label":"UniProt Q9NQX6","url":"https://www.uniprot.org/uniprotkb/Q9NQX6/entry"},{"label":"NCBI Gene 55422","url":"https://www.ncbi.nlm.nih.gov/gene/55422"},{"label":"Ensembl ENSG00000130844","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130844"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["nasopharyngeal","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF331","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:15489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15489","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NQX6","url":"https://www.uniprot.org/uniprotkb/Q9NQX6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000130844","url":"https://platform.opentargets.org/target/ENSG00000130844/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen ZNF331","url":"https://www.intogen.org/search?gene=ZNF331","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:15489","ensembl":"ENSG00000130844","uniprot":"Q9NQX6","entrez":"55422","biology":"May be involved in transcriptional regulation. May play a role in spermatogenesis. Location: Nucleus (UniProt). Locus 19q13.42 (HGNC).","whereFound":["Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/znf331/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}