{"entity":{"id":"znf395","kind":"target","name":"ZNF395","aka":["zinc finger protein 395","Zinc finger protein 395","PRF-1","HDBP2","DKFZp434K1210"],"tldr":"ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.","summary":"Plays a role in papillomavirus genes transcription.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Non-Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18737","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18737"},{"label":"UniProt Q9H8N7","url":"https://www.uniprot.org/uniprotkb/Q9H8N7/entry"},{"label":"NCBI Gene 55893","url":"https://www.ncbi.nlm.nih.gov/gene/55893"},{"label":"Ensembl ENSG00000186918","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186918"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF395","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18737","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18737","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H8N7","url":"https://www.uniprot.org/uniprotkb/Q9H8N7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZNF395","url":"https://www.intogen.org/search?gene=ZNF395","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18737","ensembl":"ENSG00000186918","uniprot":"Q9H8N7","entrez":"55893","biology":"Plays a role in papillomavirus genes transcription. Location: Cytoplasm; Nucleus (UniProt). Locus 8p21.1 (HGNC).","whereFound":["Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/znf395/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}