{"entity":{"id":"znf429","kind":"target","name":"ZNF429","aka":["zinc finger protein 429","Zinc finger protein 429"],"tldr":"ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.","summary":"May be involved in transcriptional regulation.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.17, genetic association 0.00, somatic mutation 0.66). IntOGen calls it a driver in 4 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20817","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20817"},{"label":"UniProt Q86V71","url":"https://www.uniprot.org/uniprotkb/Q86V71/entry"},{"label":"NCBI Gene 353088","url":"https://www.ncbi.nlm.nih.gov/gene/353088"},{"label":"Ensembl ENSG00000197013","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197013"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["urothelial","hcc","prostate","cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF429","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:20817","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20817","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86V71","url":"https://www.uniprot.org/uniprotkb/Q86V71/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000197013","url":"https://platform.opentargets.org/target/ENSG00000197013/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"},{"label":"IntOGen ZNF429","url":"https://www.intogen.org/search?gene=ZNF429","note":"driver in 4 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:20817","ensembl":"ENSG00000197013","uniprot":"Q86V71","entrez":"353088","biology":"May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/znf429/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}