{"entity":{"id":"znf462","kind":"target","name":"ZNF462","aka":["zinc finger protein 462","Zinc finger protein 462","DKFZP762N2316","KIAA1803","Zfp462"],"tldr":"ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.17, animal model 0.34, genetic association 0.77).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21684"},{"label":"UniProt Q96JM2","url":"https://www.uniprot.org/uniprotkb/Q96JM2/entry"},{"label":"NCBI Gene 58499","url":"https://www.ncbi.nlm.nih.gov/gene/58499"},{"label":"Ensembl ENSG00000148143","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148143"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF462","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21684","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96JM2","url":"https://www.uniprot.org/uniprotkb/Q96JM2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000148143","url":"https://platform.opentargets.org/target/ENSG00000148143/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"}],"hgnc":"HGNC:21684","ensembl":"ENSG00000148143","uniprot":"Q96JM2","entrez":"58499","biology":"Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation. Location: Nucleus (UniProt). Locus 9q31.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/znf462/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}