{"entity":{"id":"znf721","kind":"target","name":"ZNF721","aka":["zinc finger protein 721","Zinc finger protein 721","KIAA1982"],"tldr":"ZNF721 (Zinc finger protein 721) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.","summary":"May be involved in transcriptional regulation.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29425","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29425"},{"label":"UniProt Q8TF20","url":"https://www.uniprot.org/uniprotkb/Q8TF20/entry"},{"label":"NCBI Gene 170960","url":"https://www.ncbi.nlm.nih.gov/gene/170960"},{"label":"Ensembl ENSG00000182903","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182903"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nasopharyngeal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF721","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29425","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29425","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8TF20","url":"https://www.uniprot.org/uniprotkb/Q8TF20/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZNF721","url":"https://www.intogen.org/search?gene=ZNF721","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29425","ensembl":"ENSG00000182903","uniprot":"Q8TF20","entrez":"170960","biology":"May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 4p16.3 (HGNC).","whereFound":["Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/znf721/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"}]}}