{"entity":{"id":"znf750","kind":"target","name":"ZNF750","aka":["zinc finger protein 750","Zinc finger protein 750","FLJ13841","Zfp750"],"tldr":"ZNF750 (Zinc finger protein 750) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Oesophageal and junctional adenocarcinoma and Non-small-cell lung cancer.","summary":"Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.96, animal model 0.39, genetic association 0.04, somatic mutation 0.81). IntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Oesophageal Adenocarcinoma, Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25843","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25843"},{"label":"UniProt Q32MQ0","url":"https://www.uniprot.org/uniprotkb/Q32MQ0/entry"},{"label":"NCBI Gene 79755","url":"https://www.ncbi.nlm.nih.gov/gene/79755"},{"label":"Ensembl ENSG00000141579","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141579"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["esophageal","oesophageal-adenocarcinoma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF750","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25843","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25843","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q32MQ0","url":"https://www.uniprot.org/uniprotkb/Q32MQ0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141579","url":"https://platform.opentargets.org/target/ENSG00000141579/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"},{"label":"IntOGen ZNF750","url":"https://www.intogen.org/search?gene=ZNF750","note":"driver in 3 cohorts (Act 0, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25843","ensembl":"ENSG00000141579","uniprot":"Q32MQ0","entrez":"79755","biology":"Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. Location: Nucleus (UniProt). Locus 17q25.3 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 2 cohorts (ESCA)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 2 cohorts (ESCA)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/znf750/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}]}}