{"entity":{"id":"znf93","kind":"target","name":"ZNF93","aka":["zinc finger protein 93","Zinc finger protein 93","HPF34","TF34","FLJ12488","ZNF505"],"tldr":"ZNF93 (Zinc finger protein 93) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.","summary":"Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognises and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13169","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13169"},{"label":"UniProt P35789","url":"https://www.uniprot.org/uniprotkb/P35789/entry"},{"label":"NCBI Gene 81931","url":"https://www.ncbi.nlm.nih.gov/gene/81931"},{"label":"Ensembl ENSG00000184635","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184635"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nasopharyngeal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF93","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:13169","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13169","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35789","url":"https://www.uniprot.org/uniprotkb/P35789/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZNF93","url":"https://www.intogen.org/search?gene=ZNF93","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13169","ensembl":"ENSG00000184635","uniprot":"P35789","entrez":"81931","biology":"Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognises and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression. Location: Nucleus (UniProt). Locus 19p12 (HGNC).","whereFound":["Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/znf93/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"}]}}