# OnCo record acns0331 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/acns0331/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "acns0331", "NCT00085735" ;
  schema:name "COG ACNS0331"@en ;
  schema:description "This trial asked whether children with average-risk medulloblastoma could safely receive less radiation. Shrinking the boost to the tumour bed was safe; cutting the dose to the whole brain and spine in young children was not, so 23.4 Gy remains the floor for most."@en ;
  schema:url <https://onco.cc/trials/acns0331/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00085735>, <https://doi.org/10.1200/JCO.20.02730> ;
  onco:status "mixed" ;
  onco:tag "nci-coverage", "paediatric", "cns", "de-escalation" ;
  onco:phase "3" ;
  schema:startDate "2004-04-30" ;
  onco:cancers <https://onco.cc/cancers/medulloblastoma/>, <https://onco.cc/cancers/medulloblastoma-wnt/>, <https://onco.cc/cancers/medulloblastoma-group-3-4/> ;
  onco:technologies <https://onco.cc/technologies/proton-therapy/>, <https://onco.cc/technologies/imrt-igrt/> ;
  onco:drugs <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/lomustine/> ;
  onco:companies <https://onco.cc/companies/childrens-oncology-group/> ;
  onco:terms <https://onco.cc/terms/late-effects/>, <https://onco.cc/terms/de-escalation/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-survivorship/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> .