# OnCo record acvr1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/acvr1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "acvr1" ;
  schema:name "ACVR1 (ALK2)"@en ;
  schema:alternateName "ALK2"@en, "ACVR1" ;
  schema:description "ACVR1 (ALK2) is the receptor that raises hepcidin, the hormone that hides iron from the bone marrow. Momelotinib and pacritinib block it as well as JAK2, which is why they improve, rather than worsen, the low red-cell counts of myelofibrosis."@en ;
  schema:url <https://onco.cc/targets/acvr1/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:171>, <https://www.uniprot.org/uniprotkb/Q04771/entry>, <https://www.ncbi.nlm.nih.gov/gene/90> ;
  onco:tag "wave5-target" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:171>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115170>, <https://www.uniprot.org/uniprotkb/Q04771/entry>, <https://www.ncbi.nlm.nih.gov/gene/90> ;
  onco:related <https://onco.cc/targets/jak2/> ;
  onco:cancers <https://onco.cc/cancers/myeloproliferative-neoplasms/>, <https://onco.cc/cancers/primary-myelofibrosis/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/momelotinib/>, <https://onco.cc/drugs/pacritinib/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/jak-stat/> .