# OnCo record adc-supply-chain (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/adc-supply-chain/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "adc-supply-chain" ;
  schema:name "The ADC supply chain (antibody, payload-linker, conjugation, fill)"@en ;
  schema:description "An antibody-drug conjugate needs three separate factories: one growing the antibody, one making the poison and its linker in sealed rooms, and one joining them. Then a fourth fills the vials. Any of the four can hold up the drug."@en ;
  schema:url <https://onco.cc/technologies/adc-supply-chain/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-C/part-211>, <https://en.wikipedia.org/wiki/Antibody-drug_conjugate> ;
  onco:status "established" ;
  onco:tag "manufacturing-wave" ;
  onco:sections <https://onco.cc/fronts/adcs/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody-manufacturing/>, <https://onco.cc/technologies/high-potency-payload-synthesis/>, <https://onco.cc/technologies/adc-cdmo-manufacturing/>, <https://onco.cc/technologies/site-specific-conjugation/>, <https://onco.cc/technologies/sterile-fill-finish/>, <https://onco.cc/technologies/downstream-purification-chromatography/>, <https://onco.cc/technologies/pharmaceutical-gmp-inspections/>, <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/enfortumab-vedotin/>, <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/brentuximab-vedotin/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/>, <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/pfizer/>, <https://onco.cc/companies/gilead/>, <https://onco.cc/companies/astellas/>, <https://onco.cc/companies/lonza/>, <https://onco.cc/companies/wuxi-xdc/>, <https://onco.cc/companies/samsung-biologics/>, <https://onco.cc/companies/abzena/>, <https://onco.cc/companies/piramal-pharma-solutions/>, <https://onco.cc/companies/sterling-pharma-solutions/>, <https://onco.cc/companies/merck-kgaa/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/> .