# OnCo record adenoma-carcinoma-sequence (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/adenoma-carcinoma-sequence/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "adenoma-carcinoma-sequence" ;
  schema:name "Adenoma-carcinoma sequence"@en ;
  schema:alternateName "adenoma to carcinoma sequence"@en, "Vogelstein model"@en, "chromosomal instability pathway"@en, "conventional pathway"@en, "APC-KRAS-TP53 sequence"@en ;
  schema:description "The adenoma-carcinoma sequence is the step-by-step route by which a normal bowel lining becomes a polyp and the polyp becomes a cancer, as genetic faults pile up over years. It is why removing polyps prevents cancer, and it was the first human cancer to be mapped this way."@en ;
  schema:url <https://onco.cc/terms/adenoma-carcinoma-sequence/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Colorectal_cancer> ;
  schema:citation <https://doi.org/10.1056/nejm198809013190901>, <https://doi.org/10.1016/0092-8674(90)90186-i>, <https://doi.org/10.1056/nejm199312303292701>, <https://doi.org/10.1056/nejmoa1100370>, <https://doi.org/10.1111/his.12055> ;
  onco:tag "gi", "colorectal" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/colon-cancer/>, <https://onco.cc/cancers/rectal-cancer/>, <https://onco.cc/cancers/fap-associated-colorectal-cancer/>, <https://onco.cc/cancers/colorectal-adenoma-like-adenocarcinoma/> ;
  onco:technologies <https://onco.cc/technologies/colorectal-screening/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/> ;
  onco:pathways <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/serrated-pathway/>, <https://onco.cc/terms/colorectal-polyp-types/>, <https://onco.cc/terms/colonoscopy/>, <https://onco.cc/terms/colonoscopy-surveillance-intervals/> .