# OnCo record adrenocortical (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/adrenocortical/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "adrenocortical" ;
  schema:name "Adrenocortical carcinoma"@en ;
  schema:alternateName "ACC"@en ;
  schema:description "Adrenocortical carcinoma is a rare, aggressive cancer of the adrenal gland that often over-produces hormones. Surgery is the only cure, mitotane is the one drug specific to it (with real toxicity), and chemotherapy or immunotherapy help only a minority."@en ;
  schema:url <https://onco.cc/cancers/adrenocortical/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Adrenocortical_carcinoma> ;
  owl:sameAs <http://www.wikidata.org/entity/Q918285> ;
  schema:citation <https://doi.org/10.1530/EJE-18-0608>, <https://doi.org/10.1056/NEJMoa1200966>, <https://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq> ;
  onco:tag "gap-fill", "endocrine", "rare" ;
  onco:technologies <https://onco.cc/technologies/robotic-surgery/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/thermal-ablation/>, <https://onco.cc/technologies/sbrt/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/vegf/> ;
  onco:drugs <https://onco.cc/drugs/mitotane/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/cabozantinib/>, <https://onco.cc/drugs/relacorilant/> ;
  onco:companies <https://onco.cc/companies/merck/>, <https://onco.cc/companies/exelixis/>, <https://onco.cc/companies/corcept/> ;
  onco:pathways <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/p53-cell-cycle/> ;
  onco:terms <https://onco.cc/terms/germline-vs-somatic/> ;
  onco:pipeline <https://onco.cc/drugs/cabozantinib/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/mitotane/> ;
  onco:standardOfCare <https://onco.cc/drugs/mitotane/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/mitotane/>, <https://onco.cc/drugs/mitotane/>, <https://onco.cc/technologies/thermal-ablation/>, <https://onco.cc/technologies/sbrt/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/cabozantinib/> .