# OnCo record ageing-tissue-field-theory (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/ageing-tissue-field-theory/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "ageing-tissue-field-theory" ;
  schema:name "Ageing tissue and clonal fields: cancer as a disease of old tissue"@en ;
  schema:alternateName "adaptive oncogenesis"@en, "ageing theory of cancer"@en, "clonal fields"@en, "somatic mosaicism and cancer"@en, "cancer as a disease of ageing"@en, "field theory of cancer"@en ;
  schema:description "Sequencing of healthy skin, gullet and blood shows that by middle age they are patchworks of mutant clones, many carrying classic cancer mutations, yet cancer stays rare until old age. The ageing tissue view says the mutations are there early and it is the tissue that changes: ageing, damage and inflammation alter which clones win. Clonal haematopoiesis in the blood is the best-measured example."@en ;
  schema:url <https://onco.cc/terms/ageing-tissue-field-theory/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Clonal_hematopoiesis> ;
  schema:citation <https://doi.org/10.1073/pnas.1501713112>, <https://doi.org/10.1038/s41416-019-0721-1>, <https://doi.org/10.1126/science.aau3879>, <https://doi.org/10.1056/NEJMoa1408617>, <https://doi.org/10.1126/science.aan4673>, <https://doi.org/10.1038/s41586-020-1961-1>, <https://doi.org/10.1038/s41568-021-00335-3> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/clonal-evolution-theory/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/driver-passenger-model/>, <https://onco.cc/terms/microenvironment-inflammation-theory/>, <https://onco.cc/terms/epigenetic-progenitor-theory/>, <https://onco.cc/pathways/clonal-haematopoiesis/>, <https://onco.cc/pathways/field-cancerisation/>, <https://onco.cc/pathways/senescence/>, <https://onco.cc/terms/senescent-cells/>, <https://onco.cc/pathways/mutagenesis-signatures/>, <https://onco.cc/technologies/chemoprevention/>, <https://onco.cc/technologies/interception-vaccination/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/terms/vaf/> ;
  onco:cancers <https://onco.cc/cancers/mds/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/esophageal/> ;
  onco:technologies <https://onco.cc/technologies/chemoprevention/>, <https://onco.cc/technologies/interception-vaccination/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/mrd-testing/> ;
  onco:targets <https://onco.cc/targets/tp53/> ;
  onco:pathways <https://onco.cc/pathways/clonal-haematopoiesis/>, <https://onco.cc/pathways/field-cancerisation/>, <https://onco.cc/pathways/senescence/>, <https://onco.cc/pathways/mutagenesis-signatures/> ;
  onco:people <https://onco.cc/people/benjamin-ebert/>, <https://onco.cc/people/michael-stratton/>, <https://onco.cc/people/charles-swanton/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-jaiswal-chip-nejm-2014/>, <https://onco.cc/key-papers/paper-martincorena-somatic-mutations-normal-skin-science-2015/>, <https://onco.cc/key-papers/paper-martincorena-science/>, <https://onco.cc/key-papers/paper-laconi-br-j-cancer/>, <https://onco.cc/key-papers/paper-kakiuchi-nat-rev-cancer/>, <https://onco.cc/key-papers/paper-yoshida-nature/>, <https://onco.cc/key-papers/paper-rozhok-proc-natl-acad-sci-u-s-a/>, <https://onco.cc/key-papers/paper-jaiswal-science/> .