# OnCo record akr1c3 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/akr1c3/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "akr1c3" ;
  schema:name "AKR1C3"@en ;
  schema:alternateName "aldo-keto reductase family 1 member C3"@en, "HSD17B5"@en, "AKR1C3" ;
  schema:description "AKR1C3 is an enzyme that makes potent male hormones and that some cancers carry in large amounts. Rather than blocking it, prodrugs use it as a key: they stay inactive until AKR1C3 inside a tumour cell converts them into a DNA-damaging drug."@en ;
  schema:url <https://onco.cc/targets/akr1c3/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:386>, <https://www.uniprot.org/uniprotkb/P42330/entry>, <https://www.ncbi.nlm.nih.gov/gene/8644>, <https://doi.org/10.1158/1078-0432.CCR-19-0551> ;
  onco:tag "pipeline-gap-target" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:386>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196139>, <https://www.uniprot.org/uniprotkb/P42330/entry>, <https://www.ncbi.nlm.nih.gov/gene/8644> ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:drugs <https://onco.cc/drugs/ast-001/>, <https://onco.cc/drugs/ast-3424/> .