# OnCo record alc1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/alc1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "alc1" ;
  schema:name "ALC1 (CHD1L)"@en ;
  schema:alternateName "ALC1"@en, "amplified in liver cancer 1"@en, "chromodomain helicase DNA binding protein 1 like"@en, "CHD1L" ;
  schema:description "ALC1 loosens packed DNA at sites of damage so it can be repaired. Cancers that already lack the BRCA repair route, such as some breast and ovarian cancers, lean on it, and losing it made such cells far more sensitive to PARP inhibitors in the laboratory; an ALC1 inhibitor is in early trials."@en ;
  schema:url <https://onco.cc/targets/alc1/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1916>, <https://www.uniprot.org/uniprotkb/Q86WJ1/entry>, <https://www.ncbi.nlm.nih.gov/gene/9557>, <https://doi.org/10.1038/s41556-020-00624-3> ;
  onco:tag "pipeline-gap-target" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1916>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131778>, <https://www.uniprot.org/uniprotkb/Q86WJ1/entry>, <https://www.ncbi.nlm.nih.gov/gene/9557> ;
  onco:related <https://onco.cc/targets/parp/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/ovarian/> ;
  onco:drugs <https://onco.cc/drugs/eis-12656/> .