# OnCo record alk-resistance-mutation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: .
@prefix onco: .
@prefix xsd: .
a schema:MedicalTest ;
onco:kind "biomarker" ;
schema:identifier "alk-resistance-mutation" ;
schema:name "ALK kinase-domain resistance mutation (G1202R and the rest)"@en ;
schema:alternateName "ALK resistance mutation"@en, "G1202R"@en, "ALK G1202R"@en, "L1196M"@en, "ALK secondary mutation"@en, "solvent front mutation"@en ;
schema:description "After a lung cancer stops responding to an ALK-blocking tablet, finding a change inside the ALK protein itself is good news: it means the cancer still depends on ALK, and a later-generation tablet is likely to work. Finding none means the opposite."@en ;
schema:url ;
schema:dateModified "2026-09-25"^^xsd:date ;
schema:citation , , ;
onco:tag "biomarker", "resistance" ;
onco:related ;
onco:cancers ;
onco:technologies , , ;
onco:targets ;
onco:pathways , , ;
onco:terms , , , ;
onco:keyPapers , , .