# OnCo record alpine (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/alpine/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "alpine", "NCT03734016" ;
  schema:name "ALPINE"@en ;
  schema:description "The first head-to-head trial in which a newer BTK inhibitor was both safer and more effective than ibrutinib."@en ;
  schema:url <https://onco.cc/trials/alpine/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03734016> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2018-11-01" ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/cll-relapsed/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/btk/> ;
  onco:drugs <https://onco.cc/drugs/zanubrutinib/>, <https://onco.cc/drugs/ibrutinib/> ;
  onco:companies <https://onco.cc/companies/beone/> ;
  onco:people <https://onco.cc/people/oyler-john/>, <https://onco.cc/people/jennifer-brown/> .