# OnCo record amifostine (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/amifostine/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "amifostine" ;
  schema:name "Amifostine"@en ;
  schema:alternateName "WR-2721"@en, "Ethyol" ;
  schema:description "Amifostine (Ethyol) is an infusion given just before chemotherapy or radiotherapy to shield the kidneys from cisplatin and the salivary glands from radiation, reducing dry mouth after head and neck treatment."@en ;
  schema:url <https://onco.cc/drugs/amifostine/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Amifostine> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=amifostine>, <https://www.cancer.gov/about-cancer/treatment/drugs/amifostine> ;
  onco:status "approved" ;
  onco:tag "nci-list", "supportive" ;
  onco:modality "Cytoprotective thiol prodrug" ;
  onco:approval "US 1995: Reduction of cumulative cisplatin renal toxicity in advanced ovarian cancer", "US 1999: Reduction of moderate to severe xerostomia from post-operative radiotherapy for head and neck cancer" ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/head-and-neck/> ;
  onco:technologies <https://onco.cc/technologies/imrt-igrt/> ;
  onco:trials <https://onco.cc/trials/nct07157033/> .