# OnCo record aminoglutethimide (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/aminoglutethimide/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "aminoglutethimide" ;
  schema:name "Aminoglutethimide"@en ;
  schema:alternateName "Orimeten"@en, "Cytadren" ;
  schema:description "Aminoglutethimide produced a medical adrenalectomy for advanced breast and prostate cancer in the 1970s and 1980s, the ancestor of today's aromatase inhibitors, and was withdrawn once selective drugs arrived."@en ;
  schema:url <https://onco.cc/drugs/aminoglutethimide/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Aminoglutethimide> ;
  schema:citation <https://en.wikipedia.org/wiki/Aminoglutethimide>, <https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200538> ;
  onco:status "historic" ;
  onco:tag "gap-fill", "chembl-universe" ;
  onco:modality "Oral steroidogenesis inhibitor" ;
  onco:approval "US 1980: Cushing's syndrome (used off label as medical adrenalectomy in breast and prostate cancer)" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/prostate/> ;
  onco:technologies <https://onco.cc/technologies/endocrine-therapy/> ;
  onco:targets <https://onco.cc/targets/aromatase/>, <https://onco.cc/targets/cyp11a1/> ;
  onco:drugs <https://onco.cc/drugs/letrozole/>, <https://onco.cc/drugs/exemestane/> ;
  onco:trials <https://onco.cc/trials/nct00006371/> .