# OnCo record aml-myelodysplasia-related (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/aml-myelodysplasia-related/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "aml-myelodysplasia-related" ;
  schema:name "AML with myelodysplasia-related gene mutations (AML-MR)"@en ;
  schema:alternateName "AML-MR"@en, "myelodysplasia-related mutations"@en, "myelodysplasia-related gene mutations"@en, "AML with myelodysplasia-related changes"@en, "AML-MRC"@en, "secondary-type mutations"@en, "secondary AML mutation signature"@en, "SRSF2 mutation"@en, "U2AF1 mutation"@en, "ZRSR2 mutation"@en, "STAG2 mutation"@en, "BCOR mutation"@en, "ASXL1 mutation"@en, "RUNX1 mutation"@en, "spliceosome mutations"@en, "splicing factor mutations"@en ;
  schema:description "Eight genes (ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1 and ZRSR2) are almost never mutated in leukaemia that arises out of nowhere but are typical of leukaemia that grew out of a smouldering marrow disorder; finding one on the diagnostic gene panel labels the AML as myelodysplasia-related, puts it in the adverse-risk group and changes the chemotherapy chosen."@en ;
  schema:url <https://onco.cc/terms/aml-myelodysplasia-related/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  onco:related <https://onco.cc/terms/eln-risk/>, <https://onco.cc/terms/cytogenetics/>, <https://onco.cc/terms/tp53-mutated/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/sf3b1-mutation/>, <https://onco.cc/terms/ipss-m-ipss-r/>, <https://onco.cc/drugs/cpx-351/>, <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/terms/allogeneic-transplant/>, <https://onco.cc/terms/secondary-malignancy/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/aml-secondary/>, <https://onco.cc/cancers/aml-older-unfit/> .