# OnCo record aml-signalling (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/aml-signalling/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "aml-signalling" ;
  schema:name "Acute myeloid leukaemia (KEGG map)"@en ;
  schema:alternateName "KEGG hsa05221"@en, "Acute myeloid leukemia"@en ;
  schema:description "KEGG's AML map shows the two hits that turn a normal blood stem cell into a leukaemia: a growth signal jammed on (FLT3, KIT or RAS) plus a broken maturation switch (fusion proteins such as PML-RARA or AML1-ETO, or mutated CEBPA and RUNX1). Drugs now exist for both halves."@en ;
  schema:url <https://onco.cc/pathways/aml-signalling/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://www.kegg.jp/pathway/hsa05221>, <https://doi.org/10.1056/NEJMra1406184> ;
  onco:related <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/menin-kmt2a/> ;
  onco:cancers <https://onco.cc/cancers/aml/> ;
  onco:targets <https://onco.cc/targets/flt3/>, <https://onco.cc/targets/kit/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/mek/>, <https://onco.cc/targets/akt/>, <https://onco.cc/targets/rxr/> ;
  onco:drugs <https://onco.cc/drugs/midostaurin/>, <https://onco.cc/drugs/gilteritinib/>, <https://onco.cc/drugs/quizartinib/>, <https://onco.cc/drugs/arsenic-trioxide/>, <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/revumenib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/menin-kmt2a/>, <https://onco.cc/pathways/transcription-addiction/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dohner-n-engl-j-med/> .