# OnCo record amplification (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/amplification/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "amplification" ;
  schema:name "Amplification"@en ;
  schema:alternateName "amplifications"@en, "amplified"@en, "gene amplification"@en, "copy number gain"@en, "copy-number gain"@en, "copy number"@en, "copy-number"@en, "extra copies"@en ;
  schema:description "When a cell carries extra copies of a gene, sometimes 50 or more instead of the normal two, so it makes far too much of that protein. HER2 amplification in breast cancer is the classic example and is what trastuzumab exploits; MET amplification is a common escape route from EGFR inhibitors in lung cancer."@en ;
  schema:url <https://onco.cc/terms/amplification/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Gene_duplication> ;
  owl:sameAs <http://www.wikidata.org/entity/Q746284> ;
  schema:citation <https://en.wikipedia.org/wiki/Gene_duplication> ;
  onco:related <https://onco.cc/terms/overexpression/>, <https://onco.cc/terms/chromosome/>, <https://onco.cc/terms/her2-low/>, <https://onco.cc/terms/resistance/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/met/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/> .