# OnCo record aneuploidy-theory-of-cancer (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/aneuploidy-theory-of-cancer/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "aneuploidy-theory-of-cancer" ;
  schema:name "Aneuploidy and chromosomal instability as the cause of cancer"@en ;
  schema:alternateName "aneuploidy theory"@en, "chromosomal theory of cancer"@en, "Boveri hypothesis"@en, "Duesberg aneuploidy hypothesis"@en, "chromosomal instability theory"@en, "chromothripsis"@en ;
  schema:description "The oldest theory of cancer, from Theodor Boveri in 1914: tumours arise from cells with the wrong number or arrangement of chromosomes. Peter Duesberg revived it in the 1990s as an alternative to gene mutations. Most solid tumours are indeed aneuploid and chromosome shattering can create several drivers at once, but chromosomal chaos is now read as an accelerator of evolution, not the sole cause."@en ;
  schema:url <https://onco.cc/terms/aneuploidy-theory-of-cancer/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Chromosome_instability> ;
  schema:citation <https://doi.org/10.1242/jcs.025742>, <https://doi.org/10.1073/pnas.95.23.13692>, <https://doi.org/10.1016/j.cell.2010.11.055>, <https://doi.org/10.1038/s41588-019-0576-7>, <https://doi.org/10.1016/j.cell.2018.08.027>, <https://doi.org/10.1016/j.ccr.2006.12.003> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/clonal-evolution-theory/>, <https://onco.cc/terms/hallmarks-synthesis/>, <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/terms/whole-genome-doubling/>, <https://onco.cc/pathways/mitotic-spindle-checkpoint/>, <https://onco.cc/terms/genome-instability-mutation/>, <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/targets/bcr-abl/> ;
  onco:cancers <https://onco.cc/cancers/cml/>, <https://onco.cc/cancers/all-leukemia/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/bcr-abl/> ;
  onco:drugs <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/docetaxel/>, <https://onco.cc/drugs/imatinib/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/mitotic-spindle-checkpoint/>, <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/pathways/cell-cycle-engine-cdks/> ;
  onco:people <https://onco.cc/people/charles-swanton/>, <https://onco.cc/people/michael-stratton/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-weaver-cancer-cell/>, <https://onco.cc/key-papers/paper-stephens-cell/>, <https://onco.cc/key-papers/paper-bakhoum-cell/>, <https://onco.cc/key-papers/paper-cortes-ciriano-nat-genet/>, <https://onco.cc/key-papers/paper-duesberg-proc-natl-acad-sci-u-s-a/>, <https://onco.cc/key-papers/paper-boveri-j-cell-sci/> .