# OnCo record apc (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/apc/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "apc" ;
  schema:name "APC"@en ;
  schema:alternateName "APC regulator of Wnt signaling pathway"@en, "Adenomatous polyposis coli protein"@en, "DP2"@en, "DP3"@en, "DP2.5"@en, "PPP1R46"@en, "APC" ;
  schema:description "APC (Adenomatous polyposis coli protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Hepatocellular carcinoma and 5 more."@en ;
  schema:url <https://onco.cc/targets/apc/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:583>, <https://www.uniprot.org/uniprotkb/P25054/entry>, <https://www.ncbi.nlm.nih.gov/gene/324>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134982> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:583>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134982>, <https://www.uniprot.org/uniprotkb/P25054/entry>, <https://www.ncbi.nlm.nih.gov/gene/324> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/biliary-tract-cancer/>, <https://onco.cc/cancers/anal/>, <https://onco.cc/cancers/neuroendocrine/> ;
  onco:drugs <https://onco.cc/drugs/nirogacestat/> ;
  onco:pathways <https://onco.cc/pathways/colorectal-cancer-signalling/>, <https://onco.cc/pathways/gastric-cancer-signalling/>, <https://onco.cc/pathways/mitotic-spindle-checkpoint/>, <https://onco.cc/pathways/wnt/> .