# OnCo record apoptosis-bcl2 (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/apoptosis-bcl2/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "apoptosis-bcl2" ;
  schema:name "Intrinsic apoptosis (BCL-2 family)"@en ;
  schema:description "Intrinsic apoptosis is the cell's self-destruct switch. BCL-2 holds it shut; BAX and BAK pull it open. Venetoclax pries BCL-2 off so the switch can fire."@en ;
  schema:url <https://onco.cc/pathways/apoptosis-bcl2/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bcl-2_family> ;
  owl:sameAs <http://www.wikidata.org/entity/Q554446> ;
  schema:citation <https://en.wikipedia.org/wiki/Bcl-2_family>, <https://doi.org/10.1126/science.3929382>, <https://doi.org/10.1158/2159-8290.CD-18-1119> ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/mantle-cell-lymphoma/> ;
  onco:targets <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/menin/>, <https://onco.cc/targets/bim/>, <https://onco.cc/targets/bax/> ;
  onco:drugs <https://onco.cc/drugs/venetoclax/> ;
  onco:terms <https://onco.cc/terms/lymphoma-bio-germinal-centre/> .