# OnCo record ar-amplification (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/ar-amplification/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "ar-amplification" ;
  schema:name "AR amplification (gene and upstream enhancer)"@en ;
  schema:alternateName "AR amplification"@en, "androgen receptor amplification"@en, "AR gain"@en, "AR copy number gain"@en, "AR enhancer amplification"@en, "Xq12 amplification"@en ;
  schema:description "Extra copies of the gene for the androgen receptor. It is almost never present before hormone treatment and is found in about half of prostate cancers that have become resistant to it, which is why the stage the sample was taken at matters more than the result itself."@en ;
  schema:url <https://onco.cc/biomarkers/ar-amplification/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/ng0495-401>, <https://doi.org/10.1016/j.cell.2018.06.039>, <https://www.cbioportal.org/study/summary?id=prad_su2c_2019> ;
  onco:tag "biomarker", "resistance" ;
  onco:related <https://onco.cc/biomarkers/ar-v7-splice-variant/>, <https://onco.cc/biomarkers/ar-ligand-binding-domain-mutation/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/>, <https://onco.cc/cancers/prostate-mhspc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:pathways <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/prostate-cancer-signalling/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/gene-amplification/>, <https://onco.cc/terms/copy-number-variation-term/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/adt/>, <https://onco.cc/terms/ctdna/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-visakorpi-androgen-receptor-amplification-nat-genet-1995/>, <https://onco.cc/key-papers/paper-quigley-structural-variation-mcrpc-cell-2018/>, <https://onco.cc/key-papers/paper-annala-ctdna-resistance-abiraterone-enzalutamide-cancer-discov-2018/>, <https://onco.cc/key-papers/paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021/> .