# OnCo record ar-ligand-binding-domain-mutation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/ar-ligand-binding-domain-mutation/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "ar-ligand-binding-domain-mutation" ;
  schema:name "AR ligand-binding-domain mutation (L702H, W742C, H875Y, T878A, F877L)"@en ;
  schema:alternateName "AR mutation"@en, "androgen receptor mutation"@en, "L702H"@en, "T878A"@en, "T877A"@en, "H875Y"@en, "F877L"@en, "F876L"@en, "W742C"@en, "AR LBD mutation"@en ;
  schema:description "A change in the part of the androgen receptor that hormone drugs attach to. Depending on which change it is, another hormone the man is already taking can switch the receptor on, or the blocking drug can start behaving as an activating one."@en ;
  schema:url <https://onco.cc/biomarkers/ar-ligand-binding-domain-mutation/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJM199505253322101>, <https://doi.org/10.1158/1078-0432.CCR-20-4805>, <https://www.cbioportal.org/study/summary?id=prad_su2c_2019> ;
  onco:tag "biomarker", "resistance" ;
  onco:related <https://onco.cc/biomarkers/ar-amplification/>, <https://onco.cc/biomarkers/ar-v7-splice-variant/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/>, <https://onco.cc/targets/cyp17a1/> ;
  onco:pathways <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/cross-resistance/>, <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/ctdna/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-taplin-ar-mutation-androgen-independent-prostate-nejm-1995/>, <https://onco.cc/key-papers/paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004/>, <https://onco.cc/key-papers/paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021/> .