# OnCo record aren0533 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/aren0533/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "aren0533", "NCT00379340" ;
  schema:name "COG AREN0533"@en ;
  schema:description "A risk-adapted Wilms tumour trial: children whose lung metastases vanished after six weeks of chemotherapy were spared lung radiation, while those with stubborn nodules or a high-risk chromosome pattern got stronger chemotherapy and did better than in the past."@en ;
  schema:url <https://onco.cc/trials/aren0533/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00379340>, <https://doi.org/10.1200/JCO.2017.77.1931>, <https://doi.org/10.1200/JCO.18.01972> ;
  onco:status "positive" ;
  onco:tag "nci-coverage", "paediatric", "kidney" ;
  onco:phase "3" ;
  schema:startDate "2007-04-30" ;
  onco:cancers <https://onco.cc/cancers/wilms-tumor/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/dactinomycin/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/etoposide/> ;
  onco:companies <https://onco.cc/companies/childrens-oncology-group/> ;
  onco:terms <https://onco.cc/terms/de-escalation/>, <https://onco.cc/terms/late-effects/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-survivorship/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dix-j-clin-oncol/>, <https://onco.cc/key-papers/paper-dix-j-clin-oncol-2018/> .