# OnCo record astra (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/astra/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "astra", "NCT01843062" ;
  schema:name "ASTRA"@en ;
  schema:description "Adding a MEK inhibitor to boost iodine uptake before ablation did not improve complete remission rates, cooling the 'redifferentiation for everyone' idea."@en ;
  schema:url <https://onco.cc/trials/astra/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01843062>, <https://ascopubs.org/doi/10.1200/JCO.21.00714> ;
  onco:status "negative" ;
  onco:tag "failure", "lesson:adjuvant-vs-active-disease" ;
  onco:phase "3" ;
  schema:startDate "2013-08-27" ;
  onco:cancers <https://onco.cc/cancers/thyroid/> ;
  onco:technologies <https://onco.cc/technologies/radioiodine-therapy/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> .