# OnCo record avf2107g (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/avf2107g/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "avf2107g" ;
  schema:name "AVF2107g"@en ;
  schema:alternateName "Hurwitz bevacizumab trial"@en ;
  schema:description "The first trial to show that blocking a tumour's blood supply lengthens life. It added about five months and created a drug class."@en ;
  schema:url <https://onco.cc/trials/avf2107g/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa032691>, <https://www.ema.europa.eu/en/medicines/human/EPAR/avastin>, <https://www.nice.org.uk/guidance/ta1136> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/antiangiogenic/> ;
  onco:targets <https://onco.cc/targets/vegf/> ;
  onco:drugs <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/leucovorin/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> .