# OnCo record b-combination-space (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-combination-space/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-combination-space" ;
  schema:name "Too many combinations to test"@en ;
  schema:description "There are thousands of possible drug pairs and sequences. Trials can test a few dozen a year."@en ;
  schema:url <https://onco.cc/bottlenecks/b-combination-space/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.11.009>, <https://doi.org/10.1038/d41573-022-00030-4>, <https://doi.org/10.1038/s41467-019-09799-2> ;
  onco:related <https://onco.cc/collections/depmap/>, <https://onco.cc/collections/drugbank-chembl/>, <https://onco.cc/ideas/idea-payload-switching/>, <https://onco.cc/ideas/idea-dual-payload-first/>, <https://onco.cc/ideas/idea-organoid-guided-adc/>, <https://onco.cc/ideas/idea-tr2-shared-control-network/>, <https://onco.cc/ideas/idea-tr2-organoid-coclinical-arms/>, <https://onco.cc/ideas/idea-tr2-alternating-vs-concurrent/>, <https://onco.cc/ideas/idea-tr2-rwe-combination-emulation/>, <https://onco.cc/ideas/idea-tr2-factorial-adjuvant-generics/>, <https://onco.cc/ideas/idea-tr2-platform-single-ethics/>, <https://onco.cc/ideas/idea-tr2-resistance-mechanism-baskets/>, <https://onco.cc/ideas/idea-tr2-combination-utility/>, <https://onco.cc/ideas/idea-tr2-combination-patent-pool/>, <https://onco.cc/ideas/idea-tr2-sequence-registry/>, <https://onco.cc/ideas/idea-tr2-bandit-allocation/>, <https://onco.cc/ideas/idea-tr2-qsp-combo-dosing/>, <https://onco.cc/ideas/idea-tr2-combo-readiness-dossier/>, <https://onco.cc/ideas/idea-tr2-rt-drug-platform/>, <https://onco.cc/ideas/idea-tr2-paediatric-combo-prea/>, <https://onco.cc/ideas/idea-tr2-combination-forecast-tournament/>, <https://onco.cc/ideas/idea-tr2-antagonism-surveillance/>, <https://onco.cc/ideas/idea-tr2-contribution-of-components-mandate/>, <https://onco.cc/ideas/idea-tr2-window-of-opportunity-triplets/>, <https://onco.cc/ideas/idea-moon-automated-combination-discovery/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/ai-drug-design/>, <https://onco.cc/technologies/functional-drug-testing/>, <https://onco.cc/technologies/organoids/>, <https://onco.cc/technologies/bh3-profiling/>, <https://onco.cc/technologies/dual-payload-adc/>, <https://onco.cc/technologies/crispr-screens/> ;
  onco:institutions <https://onco.cc/institutions/nci/>, <https://onco.cc/institutions/broad-institute/> ;
  onco:terms <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/adc-sequencing/>, <https://onco.cc/terms/first-line/> ;
  onco:trials <https://onco.cc/trials/stampede/>, <https://onco.cc/trials/myelomatch/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-palmer-cell/>, <https://onco.cc/key-papers/paper-upadhaya-nat-rev-drug-discov/>, <https://onco.cc/key-papers/paper-menden-nat-commun/> .