# OnCo record b-early-detection (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-early-detection/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-early-detection" ;
  schema:name "The hardest cancers are found late"@en ;
  schema:description "Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely."@en ;
  schema:url <https://onco.cc/bottlenecks/b-early-detection/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.aay9040>, <https://doi.org/10.1016/S0140-6736(21)00731-5>, <https://doi.org/10.1056/NEJMoa1102873>, <https://seer.cancer.gov/statfacts/> ;
  onco:related <https://onco.cc/roadmaps/early-detection-roadmap/>, <https://onco.cc/ideas/idea-mced-new-onset-diabetes/>, <https://onco.cc/ideas/idea-mced-plus-fapi/>, <https://onco.cc/ideas/idea-hcc-blood-surveillance/>, <https://onco.cc/ideas/idea-non-endoscopic-barretts-screening/>, <https://onco.cc/collections/seer/>, <https://onco.cc/collections/globocan/>, <https://onco.cc/ideas/idea-prev-mced-change-control-plan/>, <https://onco.cc/ideas/idea-prev-interval-cancer-audit-blood-tests/>, <https://onco.cc/ideas/idea-prev-ldct-ai-negative-triage/>, <https://onco.cc/ideas/idea-prev-opportunistic-ct-ai-registry/>, <https://onco.cc/ideas/idea-prev-pancreas-ai-prediagnostic-ct/>, <https://onco.cc/ideas/idea-prev-new-onset-diabetes-pancreas-pathway/>, <https://onco.cc/ideas/idea-prev-breath-voc-symptomatic-ruleout/>, <https://onco.cc/ideas/idea-prev-urine-dna-haematuria-triage/>, <https://onco.cc/ideas/idea-prev-weight-loss-auto-alert/>, <https://onco.cc/ideas/idea-prev-cgm-glycaemic-drift-pancreas/>, <https://onco.cc/ideas/idea-prev-ehr-symptom-signature-prompts/>, <https://onco.cc/ideas/idea-prev-mced-non-specific-symptom-triage/>, <https://onco.cc/ideas/idea-prev-blood-count-trend-flags/>, <https://onco.cc/ideas/idea-prev-blood-crc-test-for-non-responders/>, <https://onco.cc/ideas/idea-prev-capsule-sponge-pharmacy/>, <https://onco.cc/ideas/idea-prev-gastric-serology-migrant-screening/>, <https://onco.cc/ideas/idea-prev-hcc-blood-surveillance-cirrhosis/>, <https://onco.cc/ideas/idea-prev-mri-first-prostate-screening-prs/>, <https://onco.cc/ideas/idea-prev-oral-cancer-community-smartphone-ai/>, <https://onco.cc/ideas/idea-prev-lmic-five-cancer-methylation-test/>, <https://onco.cc/ideas/idea-prev-fragmentomics-first-tier/>, <https://onco.cc/ideas/idea-prev-live-stage-dashboard/>, <https://onco.cc/ideas/idea-prev-open-stage-shift-microsimulation/>, <https://onco.cc/ideas/idea-prev-emergency-department-cancer-test/>, <https://onco.cc/ideas/idea-prev-ebv-dna-npc-screening-scaleup/>, <https://onco.cc/ideas/idea-prev-dental-oral-exam-standard/>, <https://onco.cc/ideas/idea-prev-bundled-cancer-check-at-60/>, <https://onco.cc/ideas/idea-moon-population-interception/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/early-detection/> ;
  onco:technologies <https://onco.cc/technologies/mced/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/fragmentomics/>, <https://onco.cc/technologies/low-dose-ct-screening/>, <https://onco.cc/technologies/colorectal-screening/>, <https://onco.cc/technologies/hcc-surveillance/>, <https://onco.cc/technologies/pancreatic-surveillance/>, <https://onco.cc/technologies/methylation-profiling/>, <https://onco.cc/technologies/radiology-ai-screening/> ;
  onco:drugs <https://onco.cc/drugs/galleri/>, <https://onco.cc/drugs/shield/> ;
  onco:companies <https://onco.cc/companies/grail/>, <https://onco.cc/companies/guardant-health/>, <https://onco.cc/companies/exact-sciences/>, <https://onco.cc/companies/freenome/>, <https://onco.cc/companies/delfi-diagnostics/>, <https://onco.cc/companies/harbinger-health/> ;
  onco:institutions <https://onco.cc/institutions/nci/>, <https://onco.cc/institutions/cruk/>, <https://onco.cc/institutions/iarc/> ;
  onco:terms <https://onco.cc/terms/stage-shift/>, <https://onco.cc/terms/ppv/>, <https://onco.cc/terms/ca19-9/>, <https://onco.cc/terms/afp/>, <https://onco.cc/terms/barretts-esophagus/>, <https://onco.cc/terms/fit-test/> ;
  onco:trials <https://onco.cc/trials/nhs-galleri/>, <https://onco.cc/trials/pathfinder-2/>, <https://onco.cc/trials/nlst-nelson/>, <https://onco.cc/trials/ukctocs/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-crosby-science/>, <https://onco.cc/key-papers/paper-menon-lancet/> .