# OnCo record b-hereditary-risk (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-hereditary-risk/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-hereditary-risk" ;
  schema:name "Inherited risk is mostly unidentified"@en ;
  schema:description "Most people who carry a high-risk cancer gene do not know it until they or a relative gets cancer."@en ;
  schema:url <https://onco.cc/bottlenecks/b-hereditary-risk/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2017.73.6314>, <https://doi.org/10.1158/1055-9965.EPI-16-0693>, <https://www.ncbi.nlm.nih.gov/clinvar/> ;
  onco:related <https://onco.cc/collections/clinvar/>, <https://onco.cc/ideas/idea-interception-vaccines/>, <https://onco.cc/ideas/idea-prev-cascade-direct-contact-relatives/>, <https://onco.cc/ideas/idea-prev-deferred-disclosure-newborn-genomes/>, <https://onco.cc/ideas/idea-prev-prs-screening-start-age/>, <https://onco.cc/ideas/idea-prev-prs-ancestry-portability-standard/>, <https://onco.cc/ideas/idea-prev-reflex-germline-testing/>, <https://onco.cc/ideas/idea-prev-traceback-deceased-probands/>, <https://onco.cc/ideas/idea-prev-vus-saturation-editing-consortium/>, <https://onco.cc/ideas/idea-prev-li-fraumeni-mri-plus-cfdna/>, <https://onco.cc/ideas/idea-prev-genetic-counselling-chatbot/>, <https://onco.cc/ideas/idea-prev-family-history-auto-match/>, <https://onco.cc/ideas/idea-prev-genetic-non-discrimination-insurance/> ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/gastric/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/risk-reducing-salpingectomy/>, <https://onco.cc/technologies/colorectal-screening/>, <https://onco.cc/technologies/chemoprevention/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/> ;
  onco:companies <https://onco.cc/companies/natera/>, <https://onco.cc/companies/illumina/> ;
  onco:terms <https://onco.cc/terms/germline-vs-somatic/>, <https://onco.cc/terms/lynch-syndrome/>, <https://onco.cc/terms/vus/>, <https://onco.cc/terms/men1-hereditary-net/>, <https://onco.cc/terms/hrd/> ;
  onco:trials <https://onco.cc/trials/olympia/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-childers-j-clin-oncol/>, <https://onco.cc/key-papers/paper-win-cancer-epidemiol-biomarkers-prev/> .