# OnCo record b-manufacturing-cell-therapy (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-manufacturing-cell-therapy" ;
  schema:name "Manufacturing cost and time for living and radioactive medicines"@en ;
  schema:description "Cell therapies take weeks to make for one patient and cost hundreds of thousands of dollars. Isotopes run short."@en ;
  schema:url <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2018.0977>, <https://doi.org/10.1056/NEJMoa1709866>, <https://www.isotopes.gov/> ;
  onco:related <https://onco.cc/roadmaps/cell-therapy-roadmap/>, <https://onco.cc/roadmaps/radiopharma-roadmap/>, <https://onco.cc/ideas/idea-in-vivo-car-solid/>, <https://onco.cc/ideas/idea-bispecific-vs-car-t-second-line/>, <https://onco.cc/ideas/idea-reg-in-vivo-cart-off-the-shelf-vial/>, <https://onco.cc/ideas/idea-reg-two-day-cart-rapid-release/>, <https://onco.cc/ideas/idea-reg-ipsc-master-bank-qualified-once/>, <https://onco.cc/ideas/idea-reg-closed-manufacturing-interop-standard/>, <https://onco.cc/ideas/idea-reg-cart-potency-reference-standards/>, <https://onco.cc/ideas/idea-reg-vein-to-vein-public-benchmark/>, <https://onco.cc/ideas/idea-reg-legacy-radium-recovery-ac225/>, <https://onco.cc/ideas/idea-reg-ac225-accelerator-pharmacopoeia/>, <https://onco.cc/ideas/idea-reg-yb176-enrichment-capacity/>, <https://onco.cc/ideas/idea-reg-medical-isotope-reactor-reserve/>, <https://onco.cc/ideas/idea-reg-alpha-emitter-portfolio/>, <https://onco.cc/ideas/idea-reg-regional-radiopharmacy-hubs/>, <https://onco.cc/ideas/idea-reg-adc-platform-designation/>, <https://onco.cc/ideas/idea-reg-hpapi-continuous-flow/>, <https://onco.cc/ideas/idea-reg-open-source-lentiviral-vectors/>, <https://onco.cc/ideas/idea-reg-non-viral-cart-manufacturing/>, <https://onco.cc/ideas/idea-reg-manufacturing-slot-exchange/>, <https://onco.cc/ideas/idea-reg-hospital-exemption-harmonised/>, <https://onco.cc/ideas/idea-reg-ai-process-control-cell-manufacturing/>, <https://onco.cc/ideas/idea-reg-early-apheresis-banking/>, <https://onco.cc/ideas/idea-reg-public-cell-therapy-foundries/>, <https://onco.cc/ideas/idea-reg-comparability-by-design-digital-twin/>, <https://onco.cc/ideas/idea-reg-isotope-supply-observatory/>, <https://onco.cc/ideas/idea-moon-in-vivo-cart-generic-price/> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/neuroendocrine/>, <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/in-vivo-car-t/>, <https://onco.cc/technologies/allogeneic-cell-therapy/>, <https://onco.cc/technologies/til-therapy/>, <https://onco.cc/technologies/tcr-t/>, <https://onco.cc/technologies/car-nk-macrophage/>, <https://onco.cc/technologies/radioligand-therapy/>, <https://onco.cc/technologies/targeted-alpha-therapy/>, <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/tisagenlecleucel/>, <https://onco.cc/drugs/ciltacabtagene-autoleucel/>, <https://onco.cc/drugs/lifileucel/>, <https://onco.cc/drugs/pluvicto/>, <https://onco.cc/drugs/lutathera/>, <https://onco.cc/drugs/ac225-psma/> ;
  onco:companies <https://onco.cc/companies/novartis/>, <https://onco.cc/companies/umoja-biopharma/>, <https://onco.cc/companies/interius/>, <https://onco.cc/companies/orna-therapeutics/>, <https://onco.cc/companies/allogene/>, <https://onco.cc/companies/caribou/>, <https://onco.cc/companies/sana-biotechnology/>, <https://onco.cc/companies/fate-therapeutics/>, <https://onco.cc/companies/terrapower-isotopes/>, <https://onco.cc/companies/orano-med/>, <https://onco.cc/companies/itm/>, <https://onco.cc/companies/curium/>, <https://onco.cc/companies/iovance/> ;
  onco:terms <https://onco.cc/terms/alpha-vs-beta/>, <https://onco.cc/terms/dosimetry/>, <https://onco.cc/terms/crs/>, <https://onco.cc/terms/icans/>, <https://onco.cc/terms/theranostics/> ;
  onco:trials <https://onco.cc/trials/eliana/>, <https://onco.cc/trials/zuma-7/>, <https://onco.cc/trials/cartitude-4/>, <https://onco.cc/trials/vision/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hernandez-jama-oncol/> .