# OnCo record b-metastasis-biology (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-metastasis-biology/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-metastasis-biology" ;
  schema:name "Metastasis is understood least and studied last"@en ;
  schema:description "Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own."@en ;
  schema:url <https://onco.cc/bottlenecks/b-metastasis-biology/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1002/cam4.2474>, <https://doi.org/10.1038/nrc.2016.25>, <https://cancergrandchallenges.org/> ;
  onco:related <https://onco.cc/ideas/idea-psma-pet-guided-mdt/>, <https://onco.cc/ideas/idea-ctdna-guided-adjuvant-crc/>, <https://onco.cc/ideas/idea-peritoneal-directed-gastric/>, <https://onco.cc/ideas/idea-bio2-antimetastatic-endpoint/>, <https://onco.cc/ideas/idea-bio2-ctc-clearance-go-nogo/>, <https://onco.cc/ideas/idea-bio2-net-blockade-perioperative/>, <https://onco.cc/ideas/idea-bio2-perioperative-betablocker-nsaid/>, <https://onco.cc/ideas/idea-bio2-premetastatic-niche-assay/>, <https://onco.cc/ideas/idea-bio2-inhaled-lung-niche-immunotherapy/>, <https://onco.cc/ideas/idea-bio2-liver-niche-kupffer-reprogramming/>, <https://onco.cc/ideas/idea-bio2-cxcr4-mobilise-then-kill/>, <https://onco.cc/ideas/idea-bio2-rapid-autopsy-commons/>, <https://onco.cc/ideas/idea-bio2-metastasis-screen-standard/>, <https://onco.cc/ideas/idea-bio2-ctc-culture-functional-testing/>, <https://onco.cc/ideas/idea-bio2-lymph-node-immune-priming/>, <https://onco.cc/ideas/idea-bio2-organotropism-atlas/>, <https://onco.cc/ideas/idea-bio2-metastasis-funding-floor/>, <https://onco.cc/ideas/idea-bio2-matrix-stiffness-prevention/>, <https://onco.cc/ideas/idea-bio2-brain-met-prevention-trials/>, <https://onco.cc/ideas/idea-bio2-oligometastatic-signature/>, <https://onco.cc/ideas/idea-moon-metastasis-prevention-indication/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/sbrt/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/psma-pet/>, <https://onco.cc/technologies/sentinel-node/>, <https://onco.cc/technologies/whole-body-mri/> ;
  onco:institutions <https://onco.cc/institutions/cruk/>, <https://onco.cc/institutions/nci/>, <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/emt/> ;
  onco:terms <https://onco.cc/terms/oligometastatic/>, <https://onco.cc/terms/oligoprogression/>, <https://onco.cc/terms/peritoneal-metastasis/>, <https://onco.cc/terms/stage-shift/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/mrd/> ;
  onco:trials <https://onco.cc/trials/mslt-ii/>, <https://onco.cc/trials/dynamic/>, <https://onco.cc/trials/circulate-japan/>, <https://onco.cc/trials/imvigor011/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dillekas-cancer-med/>, <https://onco.cc/key-papers/paper-steeg-nat-rev-cancer/> .