# OnCo record b-preclinical-models (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-preclinical-models/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-preclinical-models" ;
  schema:name "Lab models that fail to predict what happens in patients"@en ;
  schema:description "Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason."@en ;
  schema:url <https://onco.cc/bottlenecks/b-preclinical-models/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1093/biostatistics/kxx069>, <https://doi.org/10.1038/483531a>, <https://www.cancermodels.org/> ;
  onco:related <https://onco.cc/collections/cancer-models/>, <https://onco.cc/collections/depmap/>, <https://onco.cc/ideas/idea-organoid-guided-adc/>, <https://onco.cc/ideas/idea-bio1-immune-matched-humanised-mice/>, <https://onco.cc/ideas/idea-bio1-co-clinical-avatar-trials/>, <https://onco.cc/ideas/idea-bio1-organoid-immune-coculture/>, <https://onco.cc/ideas/idea-bio1-tumour-on-chip-penetration/>, <https://onco.cc/ideas/idea-bio1-in-silico-trials-dose/>, <https://onco.cc/ideas/idea-bio1-preclinical-preregistration/>, <https://onco.cc/ideas/idea-bio1-multicentre-mouse-trials/>, <https://onco.cc/ideas/idea-bio1-model-predictivity-benchmark/>, <https://onco.cc/ideas/idea-bio1-negative-preclinical-repository/>, <https://onco.cc/ideas/idea-bio1-tumour-slice-cultures/>, <https://onco.cc/ideas/idea-bio1-metastatic-niche-models/>, <https://onco.cc/ideas/idea-bio1-aged-comorbid-models/>, <https://onco.cc/ideas/idea-bio1-comparative-oncology-dogs/>, <https://onco.cc/ideas/idea-bio1-zebrafish-avatars/>, <https://onco.cc/ideas/idea-bio1-multi-organ-chip-tox/>, <https://onco.cc/ideas/idea-bio1-rare-cancer-organoid-bank/>, <https://onco.cc/ideas/idea-bio1-organoid-assay-clinical-validation/>, <https://onco.cc/ideas/idea-bio1-organoid-cell-therapy-potency/>, <https://onco.cc/ideas/idea-bio1-somatic-crispr-gemms/>, <https://onco.cc/ideas/idea-bio1-ctc-derived-explants/>, <https://onco.cc/ideas/idea-bio1-model-authentication-mandate/>, <https://onco.cc/ideas/idea-bio1-reverse-translation-resistance-models/>, <https://onco.cc/ideas/idea-bio1-ex-vivo-perfused-tumour/>, <https://onco.cc/ideas/idea-bio1-model-patient-matching/>, <https://onco.cc/ideas/idea-bio1-virtual-cell-perturbation/>, <https://onco.cc/ideas/idea-moon-self-driving-cancer-labs/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/organoids/>, <https://onco.cc/technologies/pdx-models/>, <https://onco.cc/technologies/functional-drug-testing/>, <https://onco.cc/technologies/pdac-organoid-pharmacotyping/>, <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/bh3-profiling/> ;
  onco:companies <https://onco.cc/companies/champions-oncology/>, <https://onco.cc/companies/xilis/>, <https://onco.cc/companies/curesponse/>, <https://onco.cc/companies/sengine/>, <https://onco.cc/companies/recursion/> ;
  onco:institutions <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/nci/>, <https://onco.cc/institutions/cold-spring-harbor/>, <https://onco.cc/institutions/francis-crick/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-wong-biostatistics/>, <https://onco.cc/key-papers/paper-begley-nature/> .