# OnCo record b-reproducibility (bottleneck). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/bottlenecks/b-reproducibility/>
  a schema:Thing ;
  onco:kind "bottleneck" ;
  schema:identifier "b-reproducibility" ;
  schema:name "Preclinical results do not reproduce"@en ;
  schema:description "Fewer than half of landmark cancer biology findings reproduce when someone else tries."@en ;
  schema:url <https://onco.cc/bottlenecks/b-reproducibility/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.7554/eLife.71601>, <https://doi.org/10.1038/483531a>, <https://doi.org/10.1371/journal.pbio.1002165>, <https://grants.nih.gov/policy-and-compliance/policy-topics/reproducibility> ;
  onco:related <https://onco.cc/collections/depmap/>, <https://onco.cc/collections/hpa/>, <https://onco.cc/collections/cancer-models/>, <https://onco.cc/collections/pubmed-europepmc/>, <https://onco.cc/ideas/idea-tr2-timestamped-eln/>, <https://onco.cc/ideas/idea-tr2-tenure-replication-credit/>, <https://onco.cc/ideas/idea-tr2-random-audit/>, <https://onco.cc/ideas/idea-tr2-paid-statistical-review/>, <https://onco.cc/ideas/idea-tr2-reference-model-panels/>, <https://onco.cc/ideas/idea-tr2-ai-external-validation-registry/>, <https://onco.cc/ideas/idea-tr2-two-lab-rule/>, <https://onco.cc/ideas/idea-tr2-preclinical-living-reviews/>, <https://onco.cc/ideas/idea-tr2-phd-replication-year/>, <https://onco.cc/ideas/idea-moon-independent-replication-institute/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/organoids/>, <https://onco.cc/technologies/pdx-models/>, <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/functional-drug-testing/> ;
  onco:institutions <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/cold-spring-harbor/>, <https://onco.cc/institutions/aacr/>, <https://onco.cc/institutions/nci/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-begley-nature/>, <https://onco.cc/key-papers/paper-freedman-plos-biol/> .