# OnCo record b7h4 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/b7h4/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "b7h4" ;
  schema:name "B7-H4 (VTCN1)"@en ;
  schema:alternateName "B7-H4"@en, "B7H4"@en, "B7x"@en, "B7S1"@en, "V-set domain containing T cell activation inhibitor 1"@en, "VTCN1" ;
  schema:description "B7-H4 is a checkpoint-like protein that many breast, ovarian and endometrial tumours carry on their surface. Antibody-drug conjugates such as puxitatug samrotecan and HS-20089 use it as a docking site to deliver a chemotherapy payload."@en ;
  schema:url <https://onco.cc/targets/b7h4/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28873>, <https://www.uniprot.org/uniprotkb/Q7Z7D3/entry>, <https://www.ncbi.nlm.nih.gov/gene/79679> ;
  onco:tag "wave5-target" ;
  onco:targetClass "checkpoint" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28873>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134258>, <https://www.uniprot.org/uniprotkb/Q7Z7D3/entry>, <https://www.ncbi.nlm.nih.gov/gene/79679> ;
  onco:related <https://onco.cc/targets/top1/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/endometrial/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/puxitatug-samrotecan/>, <https://onco.cc/drugs/hs-20089/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/immune-desert-exclusion/> .