# OnCo record backbone-add-on (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/backbone-add-on/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "backbone-add-on" ;
  schema:name "Backbone, add-on and monotherapy"@en ;
  schema:alternateName "backbone"@en, "chemotherapy backbone"@en, "backbone therapy"@en, "add-on"@en, "add-on therapy"@en, "monotherapy"@en, "single agent"@en, "single-agent"@en, "single-agent activity"@en, "combination partner"@en, "chemotherapy backbones"@en, "single agents"@en ;
  schema:description "Trial-design vocabulary: the backbone is the established treatment everyone in the trial receives; the add-on is the new drug tested on top of it; monotherapy means the drug alone. Most modern approvals are add-ons to a backbone."@en ;
  schema:url <https://onco.cc/terms/backbone-add-on/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Combination_therapy> ;
  schema:citation <https://en.wikipedia.org/wiki/Combination_therapy> ;
  onco:related <https://onco.cc/terms/doublet-triplet/>, <https://onco.cc/terms/control-arm/>, <https://onco.cc/terms/orr/>, <https://onco.cc/terms/de-escalation/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> .