# OnCo record basal-cell-carcinoma-signalling (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/basal-cell-carcinoma-signalling/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "basal-cell-carcinoma-signalling" ;
  schema:name "Basal cell carcinoma (KEGG map)"@en ;
  schema:alternateName "KEGG hsa05217"@en, "Basal cell carcinoma"@en ;
  schema:description "KEGG's basal cell carcinoma map is the Hedgehog pathway: loss of the brake PTCH1 or activation of SMO leaves GLI transcription factors permanently on. Hedgehog inhibitors (vismodegib, sonidegib) shut this down in advanced disease."@en ;
  schema:url <https://onco.cc/pathways/basal-cell-carcinoma-signalling/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://www.kegg.jp/pathway/hsa05217>, <https://doi.org/10.1038/nrc2503> ;
  onco:related <https://onco.cc/pathways/hedgehog/> ;
  onco:cancers <https://onco.cc/cancers/basal-cell-carcinoma/> ;
  onco:targets <https://onco.cc/targets/smoothened/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/vismodegib/>, <https://onco.cc/drugs/sonidegib/>, <https://onco.cc/drugs/cemiplimab/> ;
  onco:pathways <https://onco.cc/pathways/hedgehog/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-epstein-nat-rev-cancer/> .